HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methoxypyridin-3-yl)boronic acid → Methyl 2-(4-(2-methoxypyridin-3-yl)pyridin-3-ylamino)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methoxypyridin-3-yl)boronic acid | HCID 2762709 | — |
| Reactant | Ethylacetate heptane | HCID 21899848 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Product | Methyl 2-(4-(2-methoxypyridin-3-yl)pyridin-3-ylamino)acetate | HCID 70663573 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-ylamino)-acetic acid methyl ester (example 176, intermediate b) and 2-methoxypyridine-3-boronic acid (CAS RN 163105-90-6) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light yellow oil (73%). MS (ESI): m/z=274.119 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-e583ce4460704828a7d0fa1f0606b8da |
| Source note | uspto-grants-2015_03 |