HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Bis(trifluoromethyl)pyridine-4-carboxylic acid → Methyl 2-(N-(2-methoxy-3,4'-bipyridin-3'-yl)-2,6-bis(trifluoromethyl)isonicotinamido)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Bis(trifluoromethyl)pyridine-4-carboxylic acid | HCID 30689135 | — |
| Reactant | Methyl 2-(3-(N,N-dimethylsulfamoyl)-N-(2-methoxy-3,4'-bipyridin-3'-yl)-5-(trifluoromethyl)benzamido)acetate | HCID 70663565 | — |
| Product | Methyl 2-(N-(2-methoxy-3,4'-bipyridin-3'-yl)-2,6-bis(trifluoromethyl)isonicotinamido)acetate | HCID 86670785 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from (2-methoxy-[3,4′]bipyridinyl-3′-ylamino)-acetic acid methyl ester (example 178, intermediate) and 2,6-bis(trifluoromethyl)isonicotinic acid (Key Organics Ltd.) after a reaction time of 48 hours. The compound was purified by silica gel chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 20:80). Light yellow solid (55%). MS (ESI): m/z=515.114 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-b219f95604d84b69a51ad5e92678c62b |
| Source note | uspto-grants-2015_03 |