N-methyl-4-o-tolylpyridin-3-amine → HCID 86670787, compound

HRID 878210Notes

Reaction equation

HRID 878210 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15].[F:16][C:17]([F:32])([F:31])[C:18]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[N:21]=[C:20]([C:28](O)=[O:29])[CH:19]=1>CCCCCCC.CCOC(C)=O>[CH3:1][N:2]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])[C:28]([C:20]1[CH:19]=[C:18]([C:17]([F:16])([F:31])[F:32])[CH:23]=[C:22]([C:24]([F:27])([F:25])[F:26])[N:21]=1)=[O:29]

Participants

4

Reactant 2

HCID 18403336N-methyl-4-o-tolylpyridin-3-amineHCID 307727424,6-Bis-trifluoroMethyl-pyridine-2-carboxylic acid

Product 1

HCID 86670787HCID 86670787, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 4,6-bis(trifluoromethyl)-2-pyridinecarboxylic acid (Bionet Research) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light brown oil (66%). MS (ESI): m/z=440.12 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-3696659f40eb41cb905c47f9b47e1836
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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