HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Fluoro-6-methoxyphenyl)boronic acid → HCID 70663321, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Fluoro-6-methoxyphenyl)boronic acid | HCID 3294524 | — |
| Reactant | Ethylacetate heptane | HCID 21899848 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Product | HCID 70663321 | HCID 70663321 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from 4-iodo-pyridin-3-ylamino)-acetic acid methyl ester (example 176, intermediate b) and 2-fluoro-6-methoxyphenylboronic acid (CAS RN 78495-63-3) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light yellow oil (34%). MS (GC_MS (TIC): m/z=290.1 [M+.].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-9f97c39364944aa0acfd47283a9794fd |
| Source note | uspto-grants-2015_03 |