2-Chloro-6-methoxypyridine-4-carboxylic acid → 2-Chloro-N-[4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-6-methoxy-N-methyl-isonicotinamide

HRID 878219Notes

Reaction equation

HRID 878219 reaction equation
FC1C=C(C=C(C(F)(F)F)C=1)[C:5]([N:7]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][C:14]=1[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[O:22][CH3:23])C)=O.[Cl:31][C:32]1[CH:33]=[C:34]([CH:38]=[C:39]([O:41][CH3:42])[N:40]=1)[C:35]([OH:37])=O>>[Cl:31][C:32]1[CH:33]=[C:34]([CH:38]=[C:39]([O:41][CH3:42])[N:40]=1)[C:35]([N:7]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][C:14]=1[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[O:22][CH3:23])[CH3:5])=[O:37]

Participants

3

Reactant 2

HCID 27821242-Chloro-6-methoxypyridine-4-carboxylic acidHCID 70663278HCID 70663278, compound

Product 1

HCID 866707922-Chloro-N-[4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-6-methoxy-N-methyl-isonicotinamide

Procedure

The title compound was prepared in analogy to example 90, from [4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine (example 129, intermediate) and 2-chloro-6-methoxy-isonicotinic acid (CAS RN 15855-06-8). Colorless solid (21%). MS (ESI): m/z=402.10 [M+H]+.

Sources & evidence

ORD record
ord-a7beabdb9e4942ad9631a1f65d51e7a5
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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