2,6-Bis(trifluoromethyl)pyridine-4-carboxylic acid → HCID 86670795, compound

Participants

Reaction Steps

The title compound was prepared in analogy to example 90, from 1-[4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-ylamino]-butan-2-one and 2,6-bis(trifluoromethyl)isonicotinic acid (Key Organics Ltd.) after a reaction time of 24 hours. The compound was purified by silica gel chromatography on a 5 g column using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100), followed by a second chromatography using preparative HPLC (Gemini NX column) and a gradient of methanol:water (with 0.05% formic acid) (80:20 to 98:2). Colorless solid (10%). MS (ESI): m/z=530.130 [M+H]+.

Provenance & Evidence