(4-Fluoro-2-methoxyphenyl)boronic acid → HCID 70663195, compound

HRID 878226Notes

Reaction equation

HRID 878226 reaction equation
I[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][CH2:9][C:10](=[O:13])[CH2:11][CH3:12].[F:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[C:17]([O:24][CH3:25])[CH:16]=1>CCCCCCC.CCOC(C)=O>[F:14][C:15]1[CH:20]=[CH:19][C:18]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[NH:8][CH2:9][C:10](=[O:13])[CH2:11][CH3:12])=[C:17]([O:24][CH3:25])[CH:16]=1

Participants

4

Reactant 2

HCID 2782672(4-Fluoro-2-methoxyphenyl)boronic acidHCID 70663554HCID 70663554, compound

Product 1

HCID 70663195HCID 70663195, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to Example 72, from 1-(4-iodo-pyridin-3-ylamino)-butan-2-one and 4-fluoro-2-methoxyphenylboronic acid (CAS RN 179899-07-1) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Yellow oil (43%). MS (ESI): m/z=289.134 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-e02d30bcea73438286169d6f209fa00c
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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