HCID 70663649, compound → HCID 70663213, compound

Participants

Reaction Steps

A solution of tert-butyl 4-(4-fluoro-2-methoxyphenyl)pyridin-3-yl((3-methyloxetan-3-yl)methyl)carbamate (0.3 g, 745 μmol) in 2,2,2-trifluorethanol (3.0 mL) was stirred in a microwave oven at 150° C. for 2 hours. The compound was purified by silica gel chromatography on a 10 g column using an MPLC (ISCO) system eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100) to give the desired compound as a light brown oil (0.111 g; 49%). MS (ESI): m/z=303.1 [M+H]+.

Provenance & Evidence