Dichloromethane → HCID 86670798, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[4-(2-benzyloxymethyl-4-methyl-2H-pyrazol-3-yl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide (70 mg, 128 μmol) in TFA (3 mL) was added CH2Cl2 (300 μL). The reaction mixture was stirred at 80° C. for 2 hours and then concentrated in vacuum. The reaction mixture was poured on 30 mL 10% aqueous NaHCO3 solution and 30 mL EtOAc and the layers were separated. The aqueous layer was extracted a second time with 30 mL EtOAc. The organic layers were washed with 30 mL brine, dried over MgSO4, filtered and concentrated under vacuum. The compound was purified by silica gel chromatography on a 20 g column using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Colorless foam (20 mg, 37%). MS (ESI): m/z=429.114 [M+H]+.

Provenance & Evidence