(4-Fluoro-2-methoxyphenyl)boronic acid → [2-Chloro-4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine

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Reaction Steps

The title compound was prepared in analogy to example 72, from (2-chloro-4-iodo-pyridin-3-yl)-methyl-amine and 4-fluoro-2-methoxyphenylboronic acid (CAS RN 179899-07-1). The compound was purified by silica gel chromatography on a 20 g column using a MPLC system eluting with a gradient of n-heptane:EtOAc (100:0 to 60:40). Light yellow solid (78%). MS (ESI): m/z=267.07 [M+H]+.

Provenance & Evidence