HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 878278Generated: November 2, 2026
B-[2-(Cyclopropyloxy)phenyl]boronic acid → HCID 70663294, compound
https://huagongshe.com/reaction/878278
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | B-[2-(Cyclopropyloxy)phenyl]boronic acid | HCID 18770201 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Product | HCID 70663294 | HCID 70663294 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-methyl-amine (example 36, intermediate b) and 2-cyclopropoxyphenylboronic acid after stirring at 90° C. for 18 hours. The compound was purified by silica gel chromatography on a 20 g column using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Light yellow oil (94%). MS (ESI): m/z=241.134 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08987307B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-b28233aa08734abf8e5e7ba7d5c86300 |
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| Source note | uspto-grants-2015_03 |
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