HCID 70663278, compound → HCID 70663664, compound

HRID 878282Notes

Reaction equation

HRID 878282 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:24]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=1)[C:5]([N:7]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][C:14]=1[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[O:22][CH3:23])[CH3:8])=[O:6].[N:31]1([S:35](C2C=C(C=C(C(F)(F)F)C=2)C(O)=O)(=[O:37])=[O:36])[CH2:34][CH2:33][CH2:32]1>>[N:31]1([S:35]([C:2]2[CH:3]=[C:4]([CH:24]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=2)[C:5]([N:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[O:22][CH3:23])[CH3:8])=[O:6])(=[O:37])=[O:36])[CH2:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 70663278HCID 70663278, compoundHCID 70663656HCID 70663656, compound

Product 1

HCID 70663664HCID 70663664, compound

Procedure

The title compound was prepared in analogy to example 90, from 4-(4-fluoro-2-methoxyphenyl)-N-methylpyridin-3-amine (example 129, intermediate) and 3-(azetidine-1-sulfonyl)-5-trifluoromethyl-benzoic acid after a reaction time of 16.5 hours. The compound was purified by silica gel chromatography on a 20 g column using an MPLC (ISCO) system eluting with EtOAc (isocratic). Colorless foam (43%). MS (ESI): m/z=524.13 [M+H]+.

Workup

  1. customThe compound was purified by silica gel chromatography on a 20 g column
  2. washeluting with EtOAc (isocratic)

Sources & evidence

ORD record
ord-63287175f42e4b0e8c196db446f33e74
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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