(4-Fluoro-2-methoxyphenyl)boronic acid → HCID 70663502, compound

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Reaction Steps

The title compound was prepared in analogy to example 72, from 4-iodo-N-((1-methyl-1H-imidazol-2-yl)methyl)pyridin-3-amine and 4-fluoro-2-methoxyphenylboronic acid after a reaction time of 18 hours at 90° C. The compound was purified by silica gel chromatography on a 20 g column using an MPLC (Flashmaster) system eluting with a gradient of CH2Cl2:MeOH (100:0 to 85:15). Light yellow solid (95%). MS (ESI): m/z=313.145 [M+H]+.

Provenance & Evidence