反应详情

The title compound was prepared in analogy to example 72, from 6-chloro-4-iodo-N-methylpyridin-3-amine (prepared according to WO2006013050) and 5-fluoro-2-methylphenylboronic acid after heating at reflux for 21 hours. The compound was purified by silica gel chromatography on a 50 g column using an MPLC system eluting with a gradient of n-heptane:EtOAc (100:0 to 50:50). Light brown solid (85%). MS (ESI): m/z=251.08 [M+H]+.

1. temperatureafter heating
2. temperatureat reflux for 21 hours
3. customThe compound was purified by silica gel chromatography on a 50 g column
4. washeluting with a gradient of n-heptane:EtOAc (100:0 to 50:50)