HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Morpholine-4-sulfonyl)-5-trifluoromethyl-benzoic acid → N-[4-(4-fluoro-2-methoxyphenyl)pyridin-3-yl]-N-methyl-3-morpholin-4-ylsulfonyl-5-(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Morpholine-4-sulfonyl)-5-trifluoromethyl-benzoic acid | HCID 17964276 | — |
| Reactant | 3-Fluoro-N-[4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-methyl-5-trifluoromethyl-benzamide | HCID 70663278 | — |
| Product | N-[4-(4-fluoro-2-methoxyphenyl)pyridin-3-yl]-N-methyl-3-morpholin-4-ylsulfonyl-5-(trifluoromethyl)benzamide | HCID 60196904 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from 4-(4-fluoro-2-methoxyphenyl)-N-methylpyridin-3-amine (example 129, intermediate) and 3-(morpholine-4-sulfonyl)-5-trifluoromethyl-benzoic acid after a reaction time of 64 hours. The compound was purified by silica gel chromatography on a 20 g column using an MPLC (ISCO) system eluting with EtOAc (isocratic). Light yellow solid (34%). MS (ESI): m/z=554.14 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-d6d420ed5e3d4ea68dcd4fc7a583979f |
| Source note | uspto-grants-2015_03 |