HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile ammonium acetate → N-[4-(2,6-Difluoro-3-methoxy-phenyl)-pyridin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile ammonium acetate | HCID 21894531 | — |
| Reactant | [4-(2,6-Difluoro-3-methoxy-phenyl)-pyridin-3-yl]-methyl-amine | HCID 70663575 | — |
| Reactant | N-[4-(2-Fluoro-6-methoxy-phenyl)-pyridin-3-yl]-3-methanesulfonyl-N-(2,2,2-trifluoro-ethyl)-5-trifluoromethyl-benzamide | HCID 86670807 | — |
| Product | N-[4-(2,6-Difluoro-3-methoxy-phenyl)-pyridin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide | HCID 70663549 | — |
Reaction Steps
The title compound was prepared in analogy to example 284, from [4-(2,6-difluoro-3-methoxy-phenyl)-pyridin-3-yl]-methyl-amine and 3-methanesulfonyl-5-trifluoromethyl-benzoyl chloride (example 223, intermediate d) and using preparative HPLC (ammonium acetate/acetonitrile) for the purification. Off-white solid (25%). MS (ESI): m/z=501.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-9d7897021222418d839c11b20911cd90 |
| Source note | uspto-grants-2015_03 |