HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoro-3-methoxybenzeneboronic acid → [4-(2,6-Difluoro-3-methoxy-phenyl)-pyridin-3-yl]-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoro-3-methoxybenzeneboronic acid | HCID 2783131 | — |
| Reactant | N-(6-Methoxy-[2,4']bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 60196806 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | [4-(2,6-Difluoro-3-methoxy-phenyl)-pyridin-3-yl]-methyl-amine | HCID 70663575 | — |
Reaction Steps
The title compound was prepared in analogy to compound 284, intermediate, from (4-iodo-pyridin-3-yl)-methyl-amine (example 98, intermediate) and 2,6-difluoro-3-methoxyphenylboronic acid and using a gradient of n-hexane:EtOAc (70:30 to 60:40) for the chromatographic purification. Brown solid (75%). MS (ESI): m/z=251.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4f5d57f48af24ae18c882602ee18fb9d |
| Source note | uspto-grants-2015_03 |