(4-Fluoro-2-methoxyphenyl)boronic acid → HCID 70663366, compound

Participants

Reaction Steps

The title compound was prepared in analogy to example 72, from 4-iodo-N-((4-methyloxazol-2-yl)methyl)pyridin-3-amine and 4-fluoro-2-methoxyphenylboronic acid after a reaction time of 23 hours at reflux. The compound was purified by silica gel chromatography on a 20 g column using an MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100), then EtOAc:MeOH (100:0 to 90:10). Off-white solid (88%). MS (ESI): m/z=314.130 [M+H]+.

Provenance & Evidence