2-Chlorophenylboronic acid → HCID 70663682, compound

Participants

Reaction Steps

The title compound was prepared in analogy to example 72, from 4-iodo-N-(oxazol-2-ylmethyl)pyridin-3-amine and 2-chlorophenylboronic acid after a reaction time of 5 hours at reflux. The compound was purified by silica gel chromatography on a 20 g column using an MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100), then EtOAc:MeOH (100:0 to 90:10). Light yellow solid (93%). MS (ESI): m/z=286.074 [M+H]+.

Provenance & Evidence