HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methanesulfonyl-5-(trifluoromethyl)benzoic acid → N-[4-(5-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methanesulfonyl-5-(trifluoromethyl)benzoic acid | HCID 21544516 | — |
| Reactant | 4-(5-Fluoro-2-methoxyphenyl)pyridin-3-amine | HCID 70663373 | — |
| Product | N-[4-(5-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-3-methanesulfonyl-5-trifluoromethyl-benzamide | HCID 70663253 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from 4-(5-fluoro-2-methoxy-phenyl)-pyridin-3-ylamine and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 114, intermediate a) after a reaction time of 18 hours. The residue was purified by column chromatography eluting with a gradient of n-hexane:EtOAc (40:60 to 20:80. Brown liquid (68%). MS (ESI): m/z=469.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-9751a23ddba946eca176b4946b78c347 |
| Source note | uspto-grants-2015_03 |