HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodopyridin-3-amine → 4-(5-Fluoro-2-methoxyphenyl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodopyridin-3-amine | HCID 819132 | — |
| Reactant | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| Product | 4-(5-Fluoro-2-methoxyphenyl)pyridin-3-amine | HCID 70663373 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from 4-iodo-pyridin-3-ylamine (CAS RN 105752-11-2) and 3-fluoro-6-methoxy-phenylboronic acid (CAS RN 179897-94-0) after a reaction time of 18 hours at reflux. The compound was purified by column chromatography eluting with a gradient of n-hexane:EtOAc (40:60 to 20:80). Yellow solid (84%). MS (ESI): m/z=219.6 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-d051e94cc9c44f549607e450600aa679 |
| Source note | uspto-grants-2015_03 |