(4-Fluoro-2-methoxyphenyl)boronic acid → 4-(4-fluoro-2-methoxyphenyl)-N,6-dimethylpyridin-3-amine

Participants

Reaction Steps

The title compound was prepared in analogy to example 72, from (4-iodo-6-methyl-pyridin-3-yl)-methyl-amine and 4-fluoro-2-methoxyphenylboronic acid after a reaction time of 14.5 hours at reflux. The compound was purified by silica gel chromatography on a 10 g column using a MPLC system eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Light brown solid (84%). MS (ESI): m/z=247.12 [M+H]+.

Provenance & Evidence