3-Methanesulfonyl-5-(trifluoromethyl)benzoic acid → N-(2-Chloro-[3,4']bipyridinyl-3'-yl)-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide

Participants

Reaction Steps

The title compound was prepared in analogy to example 90, from 2-chloro-N-methyl-3,4′-bipyridin-3′-amine and 3-(methylsulfonyl)-5-(trifluoromethyl)benzoic acid (example 114, intermediate a) after a reaction time of 18 hours. The compound was purified by silica gel chromatography on a 20 g column using an MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Light brown foam (12%). MS (ESI): m/z=470.055 [M+H]+.

Provenance & Evidence