HCID 70663587, compound → HCID 86670827, compound

HRID 878375Notes

Reaction equation

HRID 878375 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH2:4][NH:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][C:19]([F:22])([F:21])[F:20].FC1C=CC=C(OC)C=1C1C=CN=CC=1N(CC(F)(F)F)[C:40](=[O:55])[C:41]1[CH:46]=[C:45]([C:47]([F:50])([F:49])[F:48])[CH:44]=[C:43]([S:51]([CH3:54])(=[O:53])=[O:52])[CH:42]=1>>[CH3:1][O:2][C:3](=[O:23])[CH2:4][N:5]([C:40](=[O:55])[C:41]1[CH:46]=[C:45]([C:47]([F:50])([F:48])[F:49])[CH:44]=[C:43]([S:51]([CH3:54])(=[O:53])=[O:52])[CH:42]=1)[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][C:19]([F:20])([F:21])[F:22]

Participants

3

Reactant 2

HCID 70663587HCID 70663587, compoundHCID 86670807N-[4-(2-Fluoro-6-methoxy-phenyl)-pyridin-3-yl]-3-methanesulfonyl-N-(2,2,2-trifluoro-ethyl)-5-trifluoromethyl-benzamide2×

Product 1

HCID 86670827HCID 86670827, compound

Procedure

The title compound was prepared in analogy to example 284, from [4-(2-trifluoromethoxy-phenyl)-pyridin-3-ylamino]-acetic acid methyl ester and 3-methanesulfonyl-5-trifluoromethyl-benzoyl chloride (example 223, intermediate d). The crude product was used in the next step without further purification. Brown sticky liquid. MS (ESI): m/z=577.2 [M+H]+.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-1ddd4fa5a03d41aba7c7280fdacf481b
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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