3-Methanesulfonyl-5-(trifluoromethyl)benzoic acid → HCID 70663600, compound

HRID 878383Notes

Reaction equation

HRID 878383 reaction equation
[CH3:1][N:2]([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][C:24]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:3](=[O:18])[C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[C:6](C(F)(F)F)[CH:5]=1.[CH3:31][S:32](C1C=C(C=C(C(F)(F)F)C=1)C(O)=O)(=[O:34])=[O:33]>>[CH3:31][S:32]([C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=1)[C:3]([N:2]([CH3:1])[C:19]1[CH:20]=[N:21][CH:22]=[CH:23][C:24]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:18])(=[O:34])=[O:33]

Participants

3

Reactant 2

HCID 215445163-Methanesulfonyl-5-(trifluoromethyl)benzoic acidHCID 86670829HCID 86670829, compound

Product 1

HCID 70663600HCID 70663600, compound

Procedure

The title compound was prepared in analogy to example 284, from methyl-(4-phenyl-pyridin-3-yl)-amine (example 322, intermediate) and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 114, intermediate a). Off-white solid (34%). MS (ESI): m/z=435.2 [M+H]+.

Sources & evidence

ORD record
ord-c55f9034b69f4f72a7b7e746897518a1
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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