Phosphoric Acid → HCID 86621457, compound

HRID 878455Notes

Reaction equation

HRID 878455 reaction equation
[C:1]1([C:7]2[S:11][C:10]([O:12][C@@H:13]3[CH:20]4[CH2:21][N:16]5[CH2:17][CH:18]([CH2:22][CH:14]3[CH2:15]5)[CH2:19]4)=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[P:23](=[O:27])([OH:26])([OH:25])[OH:24]>CO>[P:23]([OH:27])([OH:26])([OH:25])=[O:24].[C:1]1([C:7]2[S:11][C:10]([O:12][C@@H:13]3[CH:20]4[CH2:21][N:16]5[CH2:17][CH:18]([CH2:22][CH:14]3[CH2:15]5)[CH2:19]4)=[N:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 1004Phosphoric Acid2×HCID 249878751026134-63-32×

Product 1

HCID 86621457HCID 86621457, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

(4s)-4-(5-Phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane free base (20 mg, 0.064 mmol) was dissolved in 1.0 mL of methanol. Meanwhile, 5 μl of 85% phosphoric acid (0.073 mmol) was diluted with 245 μl methanol. The phosphoric acid solution was then added dropwise to the (4s)-4-(5-phenyl-1,3,4-thiadiazol-2-yloxy)-1-azatricyclo[3.3.1.13,7]decane free base solution while stirring. The vial was removed from the stir plate after the addition. The dihydrogen phosphate anhydrate crystallized upon standing.

Workup

  1. customThe vial was removed from the stir plate
  2. additionafter the addition
  3. customThe dihydrogen phosphate anhydrate crystallized

Sources & evidence

ORD record
ord-a015f9dcd8ea49e887cf0faf7776554e
Source dataset
uspto-grants-2015_03
Patent number
US08987453B2

Reaction notes

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