Acetic Acid → HCID 66778756, compound

HRID 878471Notes

Reaction equation

HRID 878471 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][C:3]=1[NH:14][C:15](=O)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([O-:24])=[O:23].[C:26](O)(=O)C>C1(C)C=CC=CC=1>[C:8]1([C:5]2[CH:6]=[CH:7][C:2]3[N:1]=[C:15]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([O:24][CH3:26])=[O:23])[NH:14][C:3]=3[CH:4]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 86662657HCID 86662657, compound

Product 1

HCID 66778756HCID 66778756, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

To a solution of 8-(4-aminobiphenyl-3-ylamino)-8-oxooctanoate (120 mg, 0.34 mmol) in toluene was added a drop of acetic acid. The reaction was heated to 110° C. overnight and concentrated. The residue was purified by biotage column chromatography to give methyl 7-(6-phenyl-1H-benzo[d]imidazol-2-yl)heptanoate (99 mg)

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by biotage column chromatography

Sources & evidence

ORD record
ord-8df072a4dd9c4e30a897c1ac3929dcab
Source dataset
uspto-grants-2015_03
Patent number
US08987468B2

Reaction notes

Loading…