HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Bromoacetophenone → (2E)-1-(4-Bromophenyl)-3-(dimethylamino)-2-propen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Bromoacetophenone | HCID 7466 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Product | (2E)-1-(4-Bromophenyl)-3-(dimethylamino)-2-propen-1-one | HCID 5376915 | 61% |
Reaction Steps
A solution of 1-(4-bromophenyl)ethanone (2.0 g, 10 mmol) in DMF-DMA (25 mL) was stirred at 100° C. for 16 h. The solution was concentrated and purified by flash column chromatography (hexanes:EtOAc=4:1˜2:1) to give the title compound (1.57 g, 61%) as an orange-brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987461B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-2c5825c09eee436ca609f4716f9e1283 |
| Source note | uspto-grants-2015_03 |