HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2E)-3-(dimethylamino)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one → 2-{5-[4-(dimethylamino)phenyl]-1H-pyrazol-1-yl}pyridine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2E)-3-(dimethylamino)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one | HCID 71285027 | — |
| Reactant | 2-Hydrazinylpyridine-4-carbonitrile hydrochloride salt | HCID 86725484 | — |
| Product | 2-{5-[4-(dimethylamino)phenyl]-1H-pyrazol-1-yl}pyridine-4-carbonitrile | HCID 86725518 | 69% |
Reaction Steps
The title compound was prepared in 69% yield from 2-hydrazinylpyridine-4-carbonitrile hydrochloride salt (PREPARATION 3) and (2E)-3-(dimethylamino)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one according to the procedure for the preparation of Example 46, part B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987461B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-ab100b53c5774baa94bbcccb23d134d4 |
| Source note | uspto-grants-2015_03 |