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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 878557Generated: October 25, 2026

(1-Methyl-1H-indazol-6-yl)methanol → 2-{5-[(1-methyl-1H-indazol-6-yl)methoxy]-1H-pyrazol-1-yl}pyridine-4-carbonitrile

https://huagongshe.com/reaction/878557

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1-Methyl-1H-indazol-6-yl)methanolHCID 44119265—
ReactantHCID 178510213HCID 178510213—
Product2-{5-[(1-methyl-1H-indazol-6-yl)methoxy]-1H-pyrazol-1-yl}pyridine-4-carbonitrileHCID 8672552411%

Reaction Steps

The title compound was prepared in 11% yield from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and (1-methyl-1H-indazol-6-yl)methanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 4.09 (3H, s), 5.40 (2H, s), 5.78 (1H, d, J=1.6 Hz), 7.19-7.17 (1H, m), 7.40 (1H, dd, J=1.2 Hz, J=5.2 Hz), 7.51 (1H, s), 7.58 (1H, d, J=2.0 Hz), 7.75 (1H, s, J=8.4 Hz), 7.99 (1H, d, J=0.4 Hz), 8.07 (1H, s), 8.71 (1H, d, J=8.4 Hz). [M+H] Calc'd for C18H14N6O, 331; Found, 331.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987461B2
Source datasetuspto-grants-2015_03
ORD IDord-837f6cad5f83487f8005819c2cb52cc5
Source noteuspto-grants-2015_03