4-(Trifluoromethyl)benzenemethanol → HCID 86725527, compound

HRID 878560Notes

Reaction equation

HRID 878560 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[F:15][C:16]([F:26])([F:25])[C:17]1[CH:22]=[CH:21][C:20]([CH2:23]O)=[CH:19][CH:18]=1>>[F:15][C:16]([F:25])([F:26])[C:17]1[CH:22]=[CH:21][C:20]([CH2:23][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][CH:3]=2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 676844-(Trifluoromethyl)benzenemethanolHCID 178510213HCID 178510213, compound

Product 1

HCID 86725527HCID 86725527, compound

Procedure

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and [4-(trifluoromethyl)phenyl]methanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 5.31 (2H, s), 5.73 (1H, d, J=1.6 Hz), 7.42 (1H, dd, J=1.2 Hz, J=4.8 Hz), 7.55-7.57 (3H, m), 7.66-7.68 (2H, m), 8.05 (1H, s), 8.70 (1H, d, J=4.8 Hz). [M+H] Calc'd for C17H11F3N4O, 345; Found, 345.

Sources & evidence

ORD record
ord-13c71023473b4b6f86d5df336e516239
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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