3-Pyridinemethanol → HCID 86725533, compound

HRID 878566Notes

Reaction equation

HRID 878566 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21]O)[CH:16]=1>>[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][CH:3]=2)[CH:16]=1

Participants

3

Reactant 2

HCID 75103-PyridinemethanolHCID 178510213HCID 178510213, compound

Product 1

HCID 86725533HCID 86725533, compound

Procedure

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and pyridin-3-ylmethanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 5.27 (2H, s), 5.78 (1H, d, J=2.0 Hz), 7.41 (1H, dd, J=1.2 Hz, J=5.2 Hz), 7.36 (1H, dd, J=4.8 Hz, J=7.6 Hz), 7.58 (1H, d, J=2.0 Hz), 7.80 (1H, d, J=8.0 Hz), 8.03 (1H, s), 8.63 (1H, dd, J=1.2 Hz, J=4.8 Hz), 8.69-8.72 (2H, m). [M+H] Calc'd for C15H11N5O, 278; Found, 278.

Sources & evidence

ORD record
ord-bc3f6bcdf7c9409380670a335999fa22
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

Loading…