4-Fluorobenzylic alcohol → HCID 86725546, compound

HRID 878579Notes

Reaction equation

HRID 878579 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][C:3]=1[CH3:15].[F:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21]O)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][C:3]=2[CH3:15])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 680224-Fluorobenzylic alcoholHCID 178430935HCID 178430935, compound

Product 1

HCID 86725546HCID 86725546, compound

Procedure

The title compound was prepared from 2-(5-hydroxy-4-methylpyrazol-1-yl)pyridine-4-carbonitrile and 4-fluorobenzyl alcohol according to the procedure for the preparation of Example 39, part C. 1H NMR (300 MHz, CDCl3): δ 1.91 (3H, s), 5.14 (2H, s), 7.26 (2H, s), 7.33-7.37 (3H, m), 7.46 (1H, s), 7.99 (1H, s), 8.62 (1H, d, J=5.1 Hz). [M+H] Calc'd for C17H13FN4O, 309; Found, 309.

Sources & evidence

ORD record
ord-4725797487774ea79f4a878244bfb5cb
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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