2-Bromobutane → HCID 86725599, compound

HRID 878635Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([OH:8])[CH:7]=1.Br[CH:12]([CH2:14][CH3:15])[CH3:13]>>[CH3:13][CH:12]([O:8][C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[CH2:9][OH:10])[CH2:14][CH3:15]

Participants

Reactant 2

HCID 65542-Bromobutane

HCID 3271485-Chloro-2-(hydroxymethyl)phenol

Product 1

HCID 86725599HCID 86725599, compound

Procedure

The title compound was prepared from 5-chloro-2-(hydroxymethyl)phenol (PREPARATION 7) and 2-bromobutane according to the procedure for the preparation of Example 111, part A. 1H NMR (400 MHz, CDCl3): δ 0.98 (3H, t, J=7.6 Hz), 1.32 (3H, d, J=6.0 Hz), 1.65-1.79 (2H, m), 2.30 (1H, t, J=6.8 Hz), 4.32-4.40 (1H, m), 4.62 (2H, d, J=6.4 Hz), 6.85 (1H, d, J=1.6 Hz), 6.89 (1H, dd, J=1.6 Hz, 7.6 Hz), 7.19 (1H, d, J=8.4 Hz).

Sources & evidence

ORD record: ord-0a3f74c9368a4d1d8676c8354b7bd4e9
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987461B2

Reaction notes

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