4-Fluorobenzyl bromide → HCID 86725606, compound

HRID 878643Notes

Reaction equation

HRID 878643 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([OH:8])[CH:7]=1.Br[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([O:8][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 55255563773873-09-9

Product 1

HCID 86725606HCID 86725606, compound

Procedure

The title compound was prepared from 5-fluoro-2-(hydroxymethyl)phenol and 4-(bromomethyl)-1-fluorobenzene according to the procedure for the preparation of Example 117, part A. 1H NMR (400 MHz, CDCl3): δ 2.07 (1H, t, J=6.8 Hz), 4.67 (2H, d, J=6.0 Hz), 5.05 (2H, s), 6.65-6.68 (2H, m), 7.07-7.11 (2H, m), 7.24-7.28 (1H, m), 7.37-7.41 (2H, m).

Sources & evidence

ORD record
ord-72248b9f5cfd4fd482b54acd5f3a1993
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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