反应详情

温度

70 °C

Charged compound 4-bromo-2-ethylbenzoic acid (2.05 g, 9.58 mmol) and methanol (20 mL) to a flask, SOCl2 (3.42 g, 28.74 mmol) was added slowly at 0° C. The reaction mixture was heated to 70° C. for three hour. Solvent was removed and the residue was dissolved in CH2Cl2, filtered, the filtrate was concentrated to a residue which was purified by flash column chromatograph to give 1.9 g of the title compound (87%).

1. customSolvent was removed
2. dissolutionthe residue was dissolved in CH2Cl2
3. filtrationfiltered
4. concentrationthe filtrate was concentrated to a residue which
5. customwas purified by flash column chromatograph