4-Bromo-2-fluoro-benzoic acid methyl ester → HCID 90205225, compound

HRID 878701Notes

Reaction equation

Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:12])[CH:3]=1.[K+].[CH:14]([B-](F)(F)F)=[CH2:15]>>[CH:14]([C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:12])[CH:3]=1)=[CH2:15]

Participants

Reactant 2

HCID 113453114-Bromo-2-fluoro-benzoic acid methyl ester

HCID 23679353Potassium vinyltrifluoroborate

Product 1

HCID 90205225HCID 90205225, compound

Procedure

The title compound was prepared from methyl 4-bromo-2-fluorobenzoate and vinyltrifluoroborate potassium salt according to the procedure for the preparation of Example 135, part A. 1H NMR (300 MHz, CDCl3): δ 3.92 (3H, s), 5.43 (1H, d, J=11.1 Hz), 5.86 (1H, d, J=17.4 Hz), 6.69 (1H, dd, J=11.1 Hz, 17.4 Hz), 7.15 (1H, d, J=12.0 Hz), 7.21 (1H, dd, J=0.9 Hz, 7.8 Hz), 7.89 (1H, t, J=8.1 Hz).

Sources & evidence

ORD record: ord-35467685e32e487bb58b0e689faaa3a2
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987461B2

Reaction notes

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