Ethyl 4-(2-chlorophenyl)-3-oxobutanoate → HCID 178510215, compound

HRID 878726Notes

Reaction equation

HRID 878726 reaction equation
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1)[NH2:2].[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][C:19](=O)[CH2:20][C:21](OCC)=[O:22]>>[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][C:19]1[CH:20]=[C:21]([OH:22])[N:1]([C:3]2[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=2)[N:2]=1

Participants

3

Reactant 2

HCID 13069496Ethyl 4-(2-chlorophenyl)-3-oxobutanoateHCID 201187142-Hydrazinylpyridine-4-carbonitrile

Product 1

HCID 178510215HCID 178510215, compoundYield 39%

Procedure

The title compound was prepared in 39% yield from 2-hydrazinylpyridine-4-carbonitrile (PREPARATION 2) and ethyl 4-(2-chlorophenyl)-3-oxobutanoate according to the procedure for the preparation of Example 158, part A.

Sources & evidence

ORD record
ord-14f9467b7cc245fca5ba290bebaddd8b
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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