ethyl 4-(3-chlorophenyl)-3-oxobutanoate → HCID 178510216, compound

HRID 878728Notes

Reaction equation

HRID 878728 reaction equation
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=1)[NH2:2].[Cl:11][C:12]1[CH:13]=[C:14]([CH2:18][C:19](=O)[CH2:20][C:21](OCC)=[O:22])[CH:15]=[CH:16][CH:17]=1>>[Cl:11][C:12]1[CH:13]=[C:14]([CH2:18][C:19]2[CH:20]=[C:21]([OH:22])[N:1]([C:3]3[CH:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][N:4]=3)[N:2]=2)[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 10538052ethyl 4-(3-chlorophenyl)-3-oxobutanoateHCID 201187142-Hydrazinylpyridine-4-carbonitrile

Product 1

HCID 178510216HCID 178510216, compoundYield 32%

Procedure

The title compound was prepared in 32% yield from 2-hydrazinylpyridine-4-carbonitrile (PREPARATION 2) and ethyl 4-(3-chlorophenyl)-3-oxobutanoate according to the procedure for the preparation of Example 158, part A.

Sources & evidence

ORD record
ord-2e205a1be0254898b28c05e4fe36acff
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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