HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(p-Chlorophenyl)cyclopropanecarboxylic acid → Methyl 3-(1-(4-chlorophenyl)cyclopropyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(p-Chlorophenyl)cyclopropanecarboxylic acid | HCID 98606 | — |
| Reactant | Potassium methyl malonate | HCID 2724687 | — |
| Product | Methyl 3-(1-(4-chlorophenyl)cyclopropyl)-3-oxopropanoate | HCID 86725681 | 78% |
Reaction Steps
The title compound was prepared in 78% yield from 1-(4-chlorophenyl)cyclopropane-1-carboxylic acid and 3-methoxy-3-oxopropanoic acid potassium salt according to the procedure for the preparation of Example 170, part A. 1H NMR (300 MHz, CDCl3): δ 1.22-1.26 (2H, m), 1.70-1.74 (2H, m), 3.35 (2H, s), 3.67 (3H, s), 7.29-7.34 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987461B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4f4d5d3724444be2b22db19c36d9b1c2 |
| Source note | uspto-grants-2015_03 |