Potassium methyl malonate → Methyl 4-(3,5-dichlorophenyl)-3-oxobutanoate

HRID 878736Notes

Reaction equation

HRID 878736 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[K+].[CH3:14][O:15][C:16](=[O:21])[CH2:17]C([O-])=O>>[Cl:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10](=[O:12])[CH2:17][C:16]([O:15][CH3:14])=[O:21])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 2724687Potassium methyl malonateHCID 64524872-(3,5-Dichlorophenyl)acetic acid

Product 1

HCID 86725683Methyl 4-(3,5-dichlorophenyl)-3-oxobutanoateYield 78%

Procedure

The title compound was prepared in 78% yield from 2-(3,5-dichlorophenyl)acetic acid and 3-methoxy-3-oxopropanoic acid potassium salt according to the procedure for the preparation of Example 170, part A.

Sources & evidence

ORD record
ord-e436b245bcf84ee496559c1e59ada50d
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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