反应详情

A suspension of ethyl 4-({(4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]-amino}sulfonyl)benzoate (1.11 g, 2.04 mmol) prepared in Example 1 and 2 mol/L aqueous sodium hydroxide solution (1.02 ml, 2.04 mmol) in ethanol (20.4 ml) was heated to reflux for 1 hour. The reaction solution was concentrated under reduced pressure, and the resulting residue is washed with diethyl ether and pentane to give sodium 4-({(4-methylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate (1.07 g, 94%) as a colorless powder.

1. temperaturewas heated
2. temperatureto reflux for 1 hour
3. concentrationThe reaction solution was concentrated under reduced pressure
4. washthe resulting residue is washed with diethyl ether and pentane