Hydrochloric Acid → HCID 86707382, compound

Participants

Reaction Steps

A suspension of ethyl 4-{[[(4′-fluorobiphenyl-4-yl)methyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate (88.0 mg, 0.16 mmol) prepared in Example 7 and 1 mol/L aqueous sodium hydroxide solution (320 μl, 0.32 mmol) in methanol (1.6 ml) was stirred at room temperature overnight, and then to the reaction solution was added 2 mol/L hydrochloric acid solution (400 μl). The mixture was extracted with chloroform twice. The organic layer was combined, washed with water and saturated brine, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (chloroform:methanol=10:0→9:1) to give 4-{[[(4′-fluorobiphenyl-4-yl)methyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoic acid (62.1 mg, 74%) as a colorless powder.

Provenance & Evidence