Hydrochloric Acid → HCID 68289685, compound

Participants

Reaction Steps

To a solution of 4-acetyl-N-(4-methylisoquinolin-3-yl)-N-[4-(trifluoromethoxy)benzyl]benzenesulfonamide (98 mg, 0.190 mmol) prepared in Example 152 in diethyl ether (2 mL) was added methylmagnesium bromide (tetrahydrofuran solution, 3 mol/L, 0.229 mmol) at 0° C., and the mixture was stirred at room temperature overnight. To the reaction solution was added 1 mol/L hydrochloric acid, and the mixture was extracted with ethyl acetate three times. The organic layer was combined, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=80:20→40:60) to give (1-hydroxy-1-methylethyl)-N-(4-methylisoquinolin-3-yl)-N-[4-(trifluoromethoxy)benzyl]benzenesulfonamide (83 mg, 82%) as a colorless powder.

Provenance & Evidence