5-Bromo-1-indanone → HCID 68289418, compound

HRID 878780Notes

Reaction equation

HRID 878780 reaction equation
BrC1C=C2C(=CC=1)C(=O)CC2.[CH:12]1([C:15]([C:21]2[CH:26]=[CH:25][C:24]([CH2:27][OH:28])=[CH:23][CH:22]=2)([OH:20])[C:16]([F:19])([F:18])[F:17])[CH2:14]C1>>[OH:28][CH2:27][C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][CH:23]=1)[C:15]([C:16]([F:17])([F:18])[F:19])([OH:20])[CH2:12][CH2:14]2

Participants

3

Reactant 2

HCID 5206955-Bromo-1-indanoneHCID 68289788HCID 68289788, compound

Product 1

HCID 68289418HCID 68289418, compound

Procedure

5-Bromoindan-1-one was treated in a similar manner to Reference examples 41-(1), (2) and (3) to give 5-(hydroxymethyl)-1-(trifluoromethyl)indan-1-ol.

Sources & evidence

ORD record
ord-d79731df92a0485db9d1befafb6c6377
Source dataset
uspto-grants-2015_03
Patent number
US08987445B2

Reaction notes

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