2,4,6-Trimethylbenzyl chloride → HCID 68184480, compound

HRID 878938Notes

Reaction equation

HRID 878938 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12]C)=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.[CH3:14][C:15]1[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]([CH3:24])[C:16]=1[CH2:17]Cl>>[CH3:14][C:15]1[CH:22]=[C:21]([CH3:23])[CH:20]=[C:19]([CH3:24])[C:16]=1[CH2:17][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([OH:12])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 741082,4,6-Trimethylbenzyl chlorideHCID 639844Methyl indole-6-carboxylate

Product 1

HCID 68184480HCID 68184480, compoundYield 47.2%

Procedure

The titled compound (790 mg) as a pale yellow solid was prepared from methyl indole-6-carboxylate (1.0 g) and 2,4,6-trimethylbenzyl chloride (1.2 g) according to the method of Example 1.

Sources & evidence

ORD record
ord-583c0dee15c74609ada1eddad1dd2c87
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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