3-Fluorobenzyl chloride → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878941Notes

Reaction equation

HRID 878941 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]Cl.[CH2:10]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:18]1.[CH2:10]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:18]1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 99743-Fluorobenzyl chlorideHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 681839322-[1-(3-fluorobenzyl)-1H-indole-6-yl]acetic acid

Procedure

The titled compound (47 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 3-fluorobenzyl chloride according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-28c959455de94111a0dca5dc3c3f64f4
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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