4-(Chloromethyl)pyridine → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878965Notes

Reaction equation

HRID 878965 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.[CH2:9]([N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=2)[CH:18]=[CH:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[N:6]1[CH:7]=[CH:8][C:3]([CH2:2][N:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=3)[CH:18]=[CH:17]2)=[CH:4][CH:5]=1.[CH2:9]([N:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH2:25][C:26]([OH:28])=[O:27])[CH:23]=2)[CH:18]=[CH:17]1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 745714-(Chloromethyl)pyridineHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68183944HCID 68183944, compound

Procedure

The titled compound (12 mg) as a yellow solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 4-(chloromethyl)pyridine according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-d4e7e44a44664ec591e286915acde579
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

Loading…