2-(Chloromethyl)anisole → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878966Notes

Reaction equation

HRID 878966 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]Cl.[CH2:11]([N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([CH2:27][C:28]([OH:30])=[O:29])[CH:25]=2)[CH:20]=[CH:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([CH2:27][C:28]([OH:30])=[O:29])[CH:25]=2)[CH:20]=[CH:19]1.[CH2:11]([N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([CH2:27][C:28]([OH:30])=[O:29])[CH:25]=2)[CH:20]=[CH:19]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 814952-(Chloromethyl)anisoleHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68183946HCID 68183946, compound

Procedure

The titled compound (29 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 2-methoxybenzyl chloride according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-9c28743334584d96aee4d819ee824616
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

Loading…