2-Chloro-5-(chloromethyl)pyridine → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878971Notes

Reaction equation

HRID 878971 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][N:3]=1.[CH2:10]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([CH2:8][N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=3)[CH:19]=[CH:18]2)=[CH:6][CH:7]=1.[CH2:10]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([CH2:26][C:27]([OH:29])=[O:28])[CH:24]=2)[CH:19]=[CH:18]1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 86707249HCID 86707249, compound

Procedure

The titled compound (26 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 2-chloro-5-(chloromethyl)pyridine according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-e74eadb9f09245389ea432f6582445bd
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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